SLC12A7 Antibody, FITC conjugated

Datasheet

Code	CSB-PA893907LC01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC12A7 Polyclonal antibody

Uniprot No.

Q9Y666

Target Names

SLC12A7

Alternative Names

D13Ertd261e antibody; Electroneutral potassium-chloride cotransporter 4 antibody; Furosemide sensitive KCl cotransporter 4 antibody; K Cl cotransporter KCC4 antibody; K-Cl cotransporter 4 antibody; Potassium/chloride transporter KCC4 antibody; S12A7_HUMAN antibody; SLC12A7 antibody; Solute carrier family 12 (potassium/chloride transporters), member 7 antibody; Solute carrier family 12 member 7 antibody; Solute carrier family 12, member 7 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Solute carrier family 12 member 7 protein (11-117AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification.

Gene References into Functions

SLC12A7 gene amplification and overexpression occurs frequently in adrenocortical carcinoma and may play a role in adrenocortical carcinoma tumorigenesis. PMID: 26454676
Negative stain transmission electron microscopy and single particle analysis of KCC4 and the aquaporin-1 AQP1 water channel, revealed the expected quaternary structures within homogeneous preparations, and thus correct protein folding and assembly. PMID: 21760919
analysis of differences in large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4 PMID: 20516068
KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state. PMID: 18984587
In the metastatic cancer tissues, KCC4 colocalizes with IGF-I or EGF. PMID: 19887603
Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown. PMID: 11976689

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

SLC12A transporter family

Tissue Specificity

Detected in muscle, brain, lung, heart and kidney.

Database Links

HGNC: 10915

OMIM: 604879

KEGG: hsa:10723

STRING: 9606.ENSP00000264930

UniGene: Hs.172613

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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